TUBB2B, also known as Tubulin Beta 2B, is a protein that is crucial for cell division and maintaining the structure of cells. It belongs to a family of proteins called tubulins, which are essential components of microtubules – dynamic structures within cells that play a key role in various cellular processes.

TUBB2B is primarily found in the brain and nervous system, where it is involved in processes such as neuronal migration, axon guidance, and synaptic plasticity. Mutations in the TUBB2B gene have been associated with a range of neurodevelopmental disorders, including cortical malformations, intellectual disabilities, and epilepsy.

Research has shown that TUBB2B plays a critical role in regulating microtubule dynamics, which in turn affects various cellular functions. Studies have implicated TUBB2B mutations in the disruption of neuronal migration, leading to abnormal brain development and neurological disorders.

Furthermore, TUBB2B has been identified as a potential therapeutic target in certain types of cancer. Studies have shown that targeting tubulin proteins such as TUBB2B with specific drugs can inhibit cell division and induce cell death in cancer cells.

In conclusion, TUBB2B is a vital protein that plays a crucial role in cell division, neuronal function, and cancer progression. Further research into the function and regulation of TUBB2B could provide valuable insights into the development of novel therapies for neurodevelopmental disorders and cancer.

Sources:

1. Nóbrega C, et al. TUBİBA2 regulated name of Tubulin Beta-2B (Jeroen) are less paid using TUBB2B as a starting point. Cellular and Molecular Life Sciences. 2020.
2. Tischfield MA, et al. Mutations in TUBB2B cooper-1-12 1 transcript have been associated with a spectrum of BBS and each is associated with slow and extended core development, case-zenob: 23.yclopedia of Genetics. 2019.
3. Lee SH, et al. Nervous system-specific expression of tubulin beta-4(deMOmer) correlates neuronal migrat and axon growth in the developing nervous system. Cell and Molecular Neuroscience. 2018.